Prof. Juan Carlos Cuevas

Theoretical Nanophysics @ UAM

Long-range transport through single G4-DNA molecules

Research into the charge transport mechanisms in single DNA molecules and their derivatives has been hindered by the inherent difficulty to form reliable electrical contacts with single molecules as well as by the absence of DNA derivatives that conduct over long distances when adsorbed on a substrate. In this work, we report on detailed and reproducible charge transport in G4-DNA adsorbed on a mica substrate. Making use of a novel benchmark process for testing molecular conductance in single polymer wires, we observed currents of tens to over 100 pA in many G4-DNA molecules over distances ranging from tens to over 100 nm, which we show to be compatible with a hopping mechanism. These results may re-ignite the interest in DNA-based wires and devices towards a practical implementation of DNA-based circuits assembled on a hard substrate.

G4-DNA

See also the accompanying 
News and Views by Elke Scheer.

You can read more about our work in the 
press release of the The Hebrew University of Jerusalem.

See also releases in 
phys.orgIEEE SpectrumAmazing Science, or ScienceDaily.

You can also read about this story in Spanish in the 
press release of the Universidad Autonoma de Madrid.

Our work has also been highlighted in different Spanish media: 
La VanguardiaLa Razón DigitalelPeriódicoteinteresa.es,Diario Siglo XXITendencias21ElDía.es elEconomista.esEl ConfidencialCatalunya Vanguardistaactualidad.es,YAHOO NoticiasSINCmedicinatv.com, etc.